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KMID : 0377519980230020105
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Chung-Ang Journal of Medicine
1998 Volume.23 No. 2 p.105 ~ p.111
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Efficacy of early phototherapy in neonatal hyperbilirubinemia
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Kim Jeong-Ah
Lim In-Seok
Lee Dong-Keun
Yoo Byung-Hoon
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Abstract
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Hyperbilirubinemia is the most common problem during the neonatal period. Physiologic jaundice becomes visible on the 2nd-3rd day of life, usually producing a peak, 5-6 mg/dl between the 3rd and 4th days, and decreasing to below 2 mg/dl between the 5th and 7th days of life. It results of increased bilirubin production following breakdown of fetal red blood cells combined with transient limitation in the conjugation of bilirubin by the liver. Because of more severe and long duration hyperbilirubinemia in Asian infants, we need close observation and early treatment in neonatal hyperbilirubinemia. We studied changed of bilirubin concentration between phototherapy and non- phototherapy groups. The results were as follows: 1) A total of 193 infants were born at St. Francisco Hospital, Seoul, between June 1 and August 31 1997. An average of serum bilirubin level of 73 infants(37.8%) was over 10 mg/dl. 2) Total serum bilirubin concentrations were significantly lower in photo-therapy group than nonphototherapy group. 3) Of non-phototherapy group, 24 infants(40%) were phototherapied due to a persisting high bilirubin level(over 15 mg/dl). 4) The bilirubin level did not show any circardian change. In conclusion, early and preventive phototherapy reduced a duration and peak of hyperbilirubinemia in the Korean infants.
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